Name: Asst. Prof. Dr. Tewin Tencomnao (ผศ.ดร.เทวิน เทนคำเนาว์)

E-mail : tewin.t@chula.ac.th

Education:

B.S. (Medical Technology, Honors), 1994, Chulalongkorn University, Bangkok, THAILAND

Ph.D. (Biochemistry and Molecular Biophysics), 2001, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia, USA

Post-Doc:
2001-2002, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, USA


Research Interests | Fellowship | Publications | Conferences|
Major Research Interests
  • Genetic polymorphisms in metabolic diseases, genetic diseases, neurodegenerative diseases, and neuropsychiatric diseases.
  • Transcriptional regulation and expression of genes involved in metabolic diseases, genetic diseases, neurodegenerative diseases, and neuropsychiatric diseases.
  • Genome-wide screening and identification of diseased tissue or cellular constituents by means of immunohistochemistry and in situ hybridization

Fellowship/Grant/Award Information :

  • Full scholarship for undergraduate study supported by Chulalongkorn University, Bangkok, Thailand (1990-1994).
  • Full scholarship for Ph.D. supported by the Royal Thai Government (1996-2001).
  • Travel award for young investigator participated in the 30 th annual meeting of American Society for Neurochemistry, New Orleans , Louisiana , USA (1999).
  • Research grant for development of new faculty staff given by Chulalongkorn university for the research project “Genetic polymorphisms of neuropsychiatric genes in Thais” ( January 2004-December 2004).
  • Research grant given by Faculty of Allied Health Sciences, Chulalongkorn university for the research project “Association study of RAGE gene polymorphism (-374T/A) and diabetic complications in Thai patients with type 2 diabetes” ( April 2004-March 2005).
  • Research g rant for development of new faculty staff given by the Thailand Research Fund (TRF) for the research project “Role of genetic polymorphism in regulating the expression of serotonin transporter” (July 2004-June 2006).

Recent Publications :

Original articles

1. “Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE”. (2004). Tencomnao T., Kapitonov D., Bieberich E., and Yu R.K. Glycoconj. J. 20, 339-351. pdf

2. “Characterization of the 5'-flanking fragment of the human GM3-synthase gene”. (2003). Zeng G.C., Gao L.Y., Xia T., Tencomnao T., and Yu R.K. Biochim. Biophys. Acta 1625, 30-35. pdf

3. “Expression of Gangliosides in an Immortalized Neural Progenitor/Stem Cell Line”. (2003). Suetake K., Liour S.S., Tencomnao T., and Yu R.K. J. Neurosci. Res. 74, 769-776. pdf

4. “Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases”. (2002). Bieberich E., MacKinnon S., Silva J., Li D.D., Tencomnao T., Irwin L., Kapitonov D., and Yu R.K. Biochemistry 41, 11479-11487. pdf

5. "Characterization of the human UDP-galactose:ceramide galactosyltransferase gene promoter". (2001). TencomnaoT., Kapitonov D., and Yu R.K. Biochim. Biophys. Acta 1517, 416-423. pdf

6. "Effect of N-Glycosylation on Turnover and Subcellular Distribution of N-Acetylgalactosaminyltransferase I and Sialyltransferase II in Neuroblastoma Cells". (2000). Bieberich E., TencomnaoT., Kapitonov D., and Yu R.K. J. Neurochem. 74, 2359-2364. pdf

7. "Protein-ribosome-mRNA display: affinity isolation of enzyme-ribosome-mRNA complexes and cDNA cloning in a single-tube reaction". (2000). Bieberich E., Kapitonov D., TencomnaoT., and Yu R.K. Anal. Biochem. 287, 294-298. pdf

Review article

1. “Genetic Polymorphisms: Implications for Neurodegenerative Diseases”. (2003). Tencomnao T. J. Allied Health Sciences of Chulalongkorn University 3, 48-56.

Abstracts in annals of Congress:

1. “Association Study of the G82S Receptor for Advanced Glycation End products (RAGE) Polymorphism with Diabetics in Thai populations”. Tencomnao T., Prasarnsuklarp A., Eiamboonsert S., Chiabchalard A., Nopponpunth A., Vongthavaravat V., and Santiyanont R. The fifth Princess Chulabhorn International Sience Congress 2: 103, 16-20 AUGUST 2004

2. “Transcriptional regulation of the human UDP-galactose: ceramide galactosyltransferase (hCGT) by GC-box and CRE”. Tencomnao T. andYu R.K. 10 th ASEAN conference in medical laboratory technology: 208, 26-30 APRIL 2004

3. “The biological activity of various garlic extracts on skin’s diseases microorganism”. Palasuwan A., Jangium W., Naumna P., Soogarun S., Pradniwat P. Sirimongkolsakul S., and Tencomnao T. 10 th ASEAN conference in medical laboratory technology: 217, 26-30 APRIL 2004

4. “Composition and localization of gangliosides in immortalized neural stem cells”. Liour S.S., Tencomnao T., Suetake K., Warsi S., Wang S., Homam N., Usuki S., Yu R.K. JOURNAL OF NEUROCHEMISTRY 85: 32-32, Suppl. 1 MAY 2003

5. “Intracellular localization of two murine NEU2 sialidases”. Kraemer S.A., Tencomnao T., Liour S.S., Yu R.K. JOURNAL OF NEUROCHEMISTRY 85: 70-70, Suppl. 1 MAY 2003

6. “Transcriptional regulation of GM3-synthase gene: a systematic search for transcription factors”. Zeng G., Gao L., Xia T., Tencomnao T., Yu R.K. JOURNAL OF NEUROCHEMISTRY 85: 79-79, Suppl. 1 MAY 2003

7. “Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases”. Bieberich E., MacKinnon S., Silva J., Li D.D., Tencomnao T., Irwin L.N., Kapitonov D., Yu R.K. JOURNAL OF NEUROCHEMISTRY 81: 9-9, Suppl. 1 JUN 2002

8. “Analysis of glycosphingolipid composition of a neural progenitor cell line”. Suetake K., Liour S.S., Tencomnao T. JOURNAL OF NEUROCHEMISTRY 81: 12-12, Suppl. 1 JUN 2002

9. “Regulation of human UDP-galactose: ceramide beta-galactosyltransferase (CGT) gene expression”. Yu R.K., Tencomnao T.JOURNAL OF NEUROCHEMISTRY 81: 34-34, Suppl. 1 JUN 2002

10. “Post-translational processing and intracellular transport of sialyltransferase-II and N-acetylgalactosaminyl- transferase I”. Bieberich E., MacKinnon S., Tencomnao T., DiSilva J., Lee D.D., Kapitonov D., Yu R.K. JOURNAL OF NEUROCHEMISTRY 78: 17-17, Suppl. 1 SEP 2001

11. “Characterization of the promoter of the human UDP-galactose : ceramide galactosyltransferase gene”. Yu R.K., Tencomnao T., Kapitonov D. MOLECULAR BIOLOGY OF THE CELL 11: 2077, Suppl. S DEC 2000

12. “Characterization of the human UDP-galactose: Ceramide galactosyltransferase promoter”. Tencomnao T., Kapitonov D., Yu R.K. JOURNAL OF NEUROCHEMISTRY 74: S25-S25, Suppl. S 2000

13. “Modulation of subcellular localization and turnover of Sialyltransferase-II wa N-acetylgalactosaminyltransferase-I by N-glycosylation”. Yu R.K., Bieberich E., Tencomnao T., Kapitonov D. MOLECULAR BIOLOGY OF THE CELL 10: 670, Suppl. S NOV 1999

14. “Activity and turnover of key regulatory enzymes in ganglioside biosynthesis: Functional role of subcellular localization and post-translational modification”. Tencomnao T., Bieberich E., Kapitonov D., Yu R.K. JOURNAL OF NEUROCHEMISTRY 72: S63-S63, Suppl. S 1999

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